What is Terpene Humulene?
BEER! Think of its smell in your mind! Have you wondered where this awesome smell comes from? We have the answer! It’s Humulene that gives ‘hoppy’ odor. Humulene is sesquiterpene, which got its name from a hops plant called Humulus lupulus. It is a commonly found terpene in nature. Humulene has found its mutual presence in cannabis and hops.
Humulene - 2,6,6,9-Tetramethyl-1,4-8-cycloundecatriene whose molecular formula is C15H24. It contains an 11-membered ring and with which three isoprene units can be found. In explaining, it has three non-conjugated C=C double bonds of which two are triply substituted, and one is doubly substituted.
Humulene is more like β-caryophyllene. Both have similar odors but differ in structure. It has a molecular weight of 204.357 g/mol.
Humulene gives effectiveness to herbal plants. It is a very effective sedative. It is an anti-cancer agent, anti-inflammatory, and anti-bacterial agent. It is Humulene with other components blocks cancer hardly. It is a good insect repellent for its smell hated by bugs. It is anti-fungal and anti-analgesic. Recent studies show that alpha-humulene has prevented the growth of tumors in rats. From a report published by a magazine shows that alpha-pinene, beta-caryophyllene, and alpha-humulene were found to be effective against the bacteria strains. Research studies have shown it to be very efficient in managing systemic inflammation, while also showing its potential to give targeted efficacy to targeted regions in the body. Humulene is also an appetite suppressant and a good pain reliever.
Humulene is prepared from Farnesyl diphosphate (FPP). The catalyst used for this process is sesquiterpene synthesis enzymes.
There are myriad methods to produce humulene in the laboratory. To know about the synthesis of Humulene, we can do a similar process in the laboratory called Corey synthesis by taking farnesol, and we prepare allylic stannane from it, whereas in Takahashi synthesis, we do the intramolecular alkylation of one allyl halide using a shielded cyanohydrin anion to synthesize Humulene. In McMurry synthesis, we do a carbonyl coupling reaction catalyzed by a titanium. In Suginome synthesis, we use geranyl fragment. In Groot synthesis, we use eucalyptus oil. Another method is that taking four component assembly and palladium-mediated cyclization, which will result in Humulene.
The boiling point of Humulene is 107 degrees Celsius or 224.6 degrees Fahrenheit – so if you are cooking with a concentrate or flower high in humulene, remember to maintain the boiling limit. Exceeding so will vaporize the humulene’s beneficial properties.
Humulene is an isomer of beta-caryophyllene. These two are frequently found together as a blend in several aromatic plants. Humulene is found in plants, such as marsh elders, pine trees, tobacco, orange orchards, & sunflower fields. Talking about the essential oils found in the aromatic plants, humelene is found in Salvia officinalis, commonly called as sage or culinary sage, Japanese spicebush (Lindera strychnifolia Uyaku), and ginseng species, the ginger family called Zingiberaceae, 29.9% of all the essential oils of Chinese laurel tree (Mentha spicata), which is a 4% of the Cordia verbenacea’s leaf extract (a bush variety in coastal tropical South America), 10% of the leaf oil found in Litsea mushaensis, and of course in cannabis.